genomic and epigenetic instability in colorectal cancer
نویسندگان
چکیده
abstract: colorectal cancer (crc) is the third most common cancer in men and the second most common cancer in women worldwide. both genetic and epigenetic alterations are common in crc and are the driving force of tumorigenesis. chromosomal instability, microsatellite instability and cpg island methylator phenotype pathways are responsible for genetic instability in colorectal cancer. chromosomal instability pathway consists of activation of proto-oncogenes and inactivation of tumor suppression genes and loss of heterozogosity (loh). in this review, we discuss genetic and epigenetic phenomena that can be suggested as biomarkers in colorectal cancer.
منابع مشابه
Epigenetic changes in colorectal cancer
Epigenetic changes frequently occur in human colorectal cancer. Genomic global hypomethylation, gene promoter region hypermethylation, histone modifications, and alteration of miRNA patterns are major epigenetic changes in colorectal cancer. Loss of imprinting(LOI) is associated with colorectal neoplasia. Folate deficiency may cause colorectal carcinogenesis by inducing gene-specific hypermethy...
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The development of neoplasia has been thought to be associated with genetic alterations for many years. In colorectal cancer two specific types of genetic instability have been defined. One is associated with chromosomal instability and the other with DNA microsatellite instability, also known as replication errors. The mechanism underlying tumorigenesis leads to profound diVerences in the path...
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عنوان ژورنال:
iranian journal of cancer preventionجلد ۶، شماره ۰۳، صفحات ۵۴-۶۳
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